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| Catalog Number | KMP3924 |
|---|---|
| Product Name | Mouse CTLA-4 Protein, His Tag |
| Product Description | The Mouse CTLA-4 Protein(KMP3924) is produced in HEK293 Cells. A DNA sequence encoding the extracellular domain of Mouse CTLA4 (NP_033973.2) (Met1-Phe162) is expressed with a polyhistidine tag at the C-terminus. |
| Molecular Name | CTLA-4 |
| Alias | CTLA-4 Protein, Mouse CTLA-4 Protein, His Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Mouse |
| Host | HEK293 Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS |
| Purification | Affinity purification |
| Molecular Weight | 15.3 kDa |
| Background | Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg). |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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