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| Catalog Number | KMP4086 |
|---|---|
| Product Name | Mouse TNFSF4 Protein, mFc Tag |
| Product Description | The Mouse TNFSF4 Protein(KMP4086) is produced in HEK293 Cells. A DNA sequence encoding the Mouse Tnfsf4 ( NP_033478.1) (Gln49-Leu198) is expressed with the Fc region of Mouse IgG1 at the N-terminus. |
| Molecular Name | TNFSF4 |
| Alias | TNFSF4 Protein, Mouse TNFSF4 Protein, mFc Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Mouse |
| Host | HEK293 Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Molecular Weight | 42.7 kDa |
| Background | OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX40. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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