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| Catalog Number | KMP4265 |
|---|---|
| Product Name | Rat ICOS ligand Protein, hFc Tag |
| Product Description | The Rat ICOS ligand Protein(KMP4265) is produced in HEK293 Cells. A DNA sequence encoding the rat ICOSLG (XP_006223893.1) (Met1-Lys261) is expressed with the Fc region of human IgG1 at the C-terminus. |
| Molecular Name | ICOS ligand |
| Alias | ICOS ligand Protein, Rat ICOS ligand Protein, hFc Tag |
| Size | 50ug, 100ug, 200ug |
| Species | Rat |
| Host | HEK293 Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Molecular Weight | 53.6 kDa |
| Background | Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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