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Catalog Number | KMP4272 |
---|---|
Product Name | Rat DKK1 Protein, His Tag |
Product Description | The Rat DKK1 Protein(KMP4272) is produced in HEK293 Cells. A DNA sequence encoding the rat DKK1 (NP_001099820.1) (Met1-His270) is expressed with a polyhistide tag at the C-terminus. |
Molecular Name | DKK1 |
Alias | DKK1 Protein, Rat DKK1 Protein, His Tag |
Size | 50ug, 100ug, 200ug |
Species | Rat |
Host | HEK293 Cells |
Purity | >95% as determined by SDS-PAGE |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Buffer | PBS, pH7.4 |
Purification | Affinity purification |
Molecular Weight | 27.44 kDa |
Background | Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers. |
Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Note | This product is for research use only. |