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| Catalog Number | MOP2075 |
|---|---|
| Product Name | Recombinant Mouse B7-h2/Icoslg/CD275/Icosl Protein, His Tag |
| Product Description | Recombinant Mouse B7-h2/Icoslg/CD275/Icosl Protein, His Tag (MOP2075) contains the mouse Icoslg(Glu47-Lys279) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
| Molecular Name | Icosl |
| Uniprot ID | Q9JHJ8 |
| Alias | B7h, GI50, GL50, B7 H2, LICOS, B7RP 1, GL50 B, ICOS L, Icoslg, Ly115l, AU044799, BG071784, mKIAA0653, icos ligand |
| Protein Family | Other protein |
| Size | 50ug, 100ug |
| Species | Mouse |
| Host | Mammalian cells |
| Molecular Weight | 25.63 kDa |
| Purity | ≥90% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per ug of the protein as determined by the LAL method. |
| Cross-Reactivity | No cross-reactivity with other antigens or proteins. |
| Buffer | PBS |
| Purification | Affinity Purification |
| Background | Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. ICOSL constructs lacking either the IgC or IgV domain demonstrates that receptor binding is mediated solely by the IgV domain but requires the IgC domain for maintaining the structural integrity of the protein. |
| Storage | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
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