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Catalog Number | KMH1829 |
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Product Name | Recombinant Human TNFRSF18/GITR Protein, Fc Tag |
Product Description | Recombinant Human TNFRSF18/GITR Protein, Fc Tag (KMH1829) contains the human TNFRSF18(Gln26-Gln161) was fused with the C-terminal Fc Tag and expressed in Mammalian cells. |
Molecular Name | TNFRSF18 |
Uniprot ID | Q9Y5U5 |
Alias | AITR, GITR, CD357, GITR D, ENERGEN, TNF receptor superfamily member 18 |
Protein Family | Other protein |
Size | 50ug, 100ug |
Species | Human |
Host | Mammalian cells |
Molecular Weight | 39.96 kDa |
Purity | ≥90% as determined by SDS-PAGE |
Endotoxin | < 1.0 EU per ug of the protein as determined by the LAL method. |
Cross-Reactivity | No cross-reactivity with other antigens or proteins. |
Buffer | PBS |
Purification | Affinity Purification |
Background | GITR (glucocorticoid-induced tumor necrosis factor receptor) also known as TNFRSF18, is a surface receptor molecule that has been shown to be involved in inhibiting the suppressive activity of T-regulatory cells and extending the survival of T-effector cells.1 GITR is involved in the regulation of T-cell receptor mediated cell death. Constitutive expression of a transfected GITR gene induces resistance to apoptosis induced by anti CD3 monoclonal antibodies. GITR ligand interferes with the suppressor activity of CD4(+) CD25(+) regulatory T-cells. |
Storage | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |