KMD Bioscience Co., Ltd.
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| Catalog Number | KMP2237 |
|---|---|
| Product Name | Rhesus Macaque CD47 Protein, His Tag, Flag Tag |
| Product Description | The Rhesus Macaque CD47 Protein(KMP2237) is produced in HEK293 Cells and the target gene encoding Gln19-Glu141 is expressed with a 6His, Flag tag at the N-terminus. |
| Molecular Weight | 14.19 kDa |
| Alias | Leukocyte Surface Antigen CD47, MER6 |
| Species | Rhesus Macaque |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purification | Affinity purification |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Uniprot | F7A802 |
| Background | CD47, also known as Integrin-Associated Protein(IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain(ECD) with a single Ig-like domain, five membrane-spanning regions with short intervening loops, and C-terminal cytoplasmic tail. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It plays an important role in memory formation and synaptic plasticity in the hippocampus. As a receptor for SIRPA, it binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cellcell adhesion, it enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. It may play a role in membrane transport and/or integrin dependent signal transduction. It also prevents premature elimination of red blood cells. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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