KMD Bioscience Co., Ltd.
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Email：info@kmdbioscience.com
| Catalog Number | KMP2726 |
|---|---|
| Product Name | Human CD40 Protein, hFc Tag |
| Product Description | The Human CD40 Protein(KMP2726) is produced in HEK293 Cells. The target gene encoding the human CD40 (NP_001241.1) (Met1-Arg193) is expressed with the Fc region of human IgG1 at the C-terminus. |
| Molecular Name | CD40 |
| Alias | Human CD40 Protein, hFc Tag, CD40 |
| Molecular Weight | 46.2 kDa |
| Species | Human |
| Size | 50ug, 100ug, 200ug |
| Host | HEK293 Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Background | CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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Email：info@kmdbioscience.com
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