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Catalog Number | KMP2825 |
---|---|
Product Name | Human TFRC Protein, hFc Tag |
Product Description | The Human TFRC Protein(KMP2825) is produced in HEK293 Cells. The target gene encoding the human TFRC (CAA25527.1) (Cys89-Phe760) is expressed with the Fc region of human IgG1 at the N-terminus. |
Molecular Name | TFRC |
Alias | Human TFRC Protein, hFc Tag, TFRC |
Molecular Weight | 103.6 kDa |
Species | Human |
Size | 50ug, 100ug, 200ug |
Host | HEK293 Cells |
Purity | >85% as determined by SDS-PAGE |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Buffer | PBS, pH7.4 |
Purification | Affinity purification |
Background | Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein that belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target. |
Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Note | This product is for research use only. |