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Human TFRC Protein, hFc Tag

Product Information
Catalog Number KMP2825
Product Name Human TFRC Protein, hFc Tag
Product Description The Human TFRC Protein(KMP2825) is produced in HEK293 Cells. The target gene encoding the human TFRC (CAA25527.1) (Cys89-Phe760) is expressed with the Fc region of human IgG1 at the N-terminus.
Molecular Name TFRC
Alias Human TFRC Protein, hFc Tag, TFRC
Molecular Weight 103.6 kDa
Species Human
Size 50ug, 100ug, 200ug
Host HEK293 Cells
Purity >85% as determined by SDS-PAGE
Endotoxin <1.0 EU/ug determined by the LAL method
Buffer PBS, pH7.4
Purification Affinity purification
Background Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein that belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.
Storage Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Note This product is for research use only.