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| Catalog Number | KMP2934 |
|---|---|
| Product Name | Human CNTF Protein, His Tag |
| Product Description | The Human CNTF Protein(KMP2934) is produced in E. coli. The target gene encoding the human CNTF (NP_000605.1) (Ala 2-Met 200) is expressed, with a polyHistide tag at the N-terminus. |
| Molecular Name | CNTF |
| Alias | Human CNTF Protein, His Tag, CNTF |
| Molecular Weight | 24.5 kDa |
| Species | Human |
| Size | 50ug, 100ug, 200ug |
| Host | E. coli |
| Purity | >90% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Background | Ciliary neurotrophic factor (CNTF) is a member of the cytokine family. It is a polypeptide hormone that has functions in promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. Its actions appear to be restricted to the nervous system. Ciliary neurotrophic factor (CNTF) has biological effects through the activation of a multi-subunit receptor complex, consisting of an extracellular CNTF binding subunit (CNTFα) and two transmembrane signal transduction proteins: glycoprotein gp130 and LIF receptor. CNTF is considered as a potent survival factor of neurons and oligodendrocyteands may be relevant in reducing tissue destruction during inflammatory attacks. CNTF also is a survival factor for neurons of the peripheral sensory sympathetic and ciliary ganglia. It has been reported that CNTF could be an agent that has therapeutic potential and possibly induces differentiation of large multipolar ganglionic phenotype in a subset of progenitors. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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