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| Catalog Number | KMP3532 |
|---|---|
| Product Name | Human TNFSF12 Protein, mFc Tag |
| Product Description | The Human TNFSF12 Protein(KMP3532) is produced in HEK293 Cells. The target gene encoding the human / cynomolgus TNFSF12 (F7HGN4) (Ser94-His249) is expressed with the Fc region of mouse IgG1 at the N-terminus. Human and Cynomolgus TNFSF12 sequences are identical. |
| Molecular Name | TNFSF12 |
| Alias | Human TNFSF12 Protein, mFc Tag, TNFSF12 |
| Molecular Weight | 43.8 kDa |
| Species | Human |
| Size | 50ug, 100ug, 200ug |
| Host | HEK293 Cells |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Purification | Affinity purification |
| Background | TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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