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Catalog Number | KMP3799 |
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Product Name | Cynomolgus TNFSF12 Protein, mFc Tag |
Product Description | The Cynomolgus TNFSF12 Protein(KMP3799) is produced in HEK293 Cells. A DNA sequence encoding the human/Cynomolgus TNFSF12 (F7HGN4) (Ser94-His249) is expressed with the Fc region of Mouse IgG1 at the N-terminus. Human and Cynomolgus TNFSF12 sequences are identical. |
Molecular Name | TNFSF12 |
Alias | TNFSF12 Protein, Cynomolgus TNFSF12 Protein, mFc Tag |
Size | 50ug, 100ug, 200ug |
Species | Cynomolgus |
Host | HEK293 Cells |
Purity | >95% as determined by SDS-PAGE |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Buffer | PBS, pH7.4 |
Purification | Affinity purification |
Molecular Weight | 43.8 kDa |
Background | TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation. |
Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Note | This product is for research use only. |