KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+86-022-82164980
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：[email protected]
| Catalog Number | MAV154 |
|---|---|
| Product Name | Recombinant Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb |
| Molecular Name | COVID-19 |
| Clonity | Recombinant mAb |
| Alias | SARS-CoV-2 Spike RBD antibody, 2019-nCoV, Coronavirus |
| Product Description | The product is specific for SARS-CoV-2 Spike protein RBD domain |
| Size | 100ug |
| Molecular Weight | 50-60kDa |
| Species | COVID-19 |
| Host | Mouse |
| Applications | ELISA, POCT, Neu, Standard |
| Purity | >95% as determined by SDS-PAGE. |
| Endotoxin | Less than 1.0 EU per μg by the LAL method |
| Buffer | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. |
| Cross-Reactivity | React with SARS-CoV-2 Spike protein RBD domain. Do not react with other SARS-CoV-2 subunits. |
| Background | A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans, causing COVID-19. A key to tackling this pandemic is to understand the receptor recognition mechanism of the virus, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor—angiotensin-converting enzyme 2 (ACE2)—in humans. Researchers determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2. In comparison with the SARS-CoV RBD, an ACE2-binding ridge in SARS-CoV-2 RBD has a more compact conformation; moreover, several residue changes in the SARS-CoV-2 RBD stabilize two virus-binding hotspots at the RBD–ACE2 interface. These structural features of SARS-CoV-2 RBD increase its ACE2-binding affinity. Additionally, we show that RaTG13, a bat coronavirus that is closely related to SARS-CoV-2, also uses human ACE2 as its receptor. Recombinant Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb can potently neutralize all SARS-CoV-2 Variants of Concern, including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2) and Omicron (B.1.1.529). |
| Storage | For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. |
| Shipping Condition | Shipped on ice packs. |
| Note | This product is used for research use only. Not for human or diagnostic use. |
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：[email protected]
Hot Line： +86-022-82164980
Technical Support：[email protected]
