KMD Bioscience Co., Ltd.
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Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
| Catalog Number | MAV155 |
|---|---|
| Product Name | Recombinant Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb (Omicron Specific) |
| Molecular Name | COVID-19 |
| Clonity | Recombinant mAb |
| Alias | SARS-CoV-2 Spike RBD antibody, 2019-nCoV, Coronavirus |
| Product Description | The product is specific for SARS-CoV-2 Spike protein RBD domain |
| Size | 100ug |
| Species | COVID-19 |
| Host | Human |
| Applications | ELISA, POCT, Neu, Standard |
| Purity | >95% as determined by SDS-PAGE. |
| Endotoxin | Less than 1.0 EU per μg by the LAL method |
| Buffer | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. |
| Cross-Reactivity | React with SARS-CoV-2 Spike protein RBD domain. Do not react with other SARS-CoV-2 subunits. |
| Background | A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans, causing COVID-19. A key to tackling this pandemic is to understand the receptor recognition mechanism of the virus, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor—angiotensin-converting enzyme 2 (ACE2)—in humans. Researchers determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2. In comparison with the SARS-CoV RBD, an ACE2-binding ridge in SARS-CoV-2 RBD has a more compact conformation; moreover, several residue changes in the SARS-CoV-2 RBD stabilize two virus-binding hotspots at the RBD–ACE2 interface. These structural features of SARS-CoV-2 RBD increase its ACE2-binding affinity. Additionally, we show that RaTG13, a bat coronavirus that is closely related to SARS-CoV-2, also uses human ACE2 as its receptor. This antibody is specific against the Omicron (B.1.1.529) and has no binding with the spike RBD of the wild type virus and other viral lineages. |
| Storage | For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. |
| Shipping Condition | Shipped on ice packs. |
| Note | This product is used for research use only. Not for human or diagnostic use. |
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
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