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Human CD40L Protein

Product Information
Catalog Number KMP2375
Product Name Human CD40L Protein
Product Description The Human CD40L Protein(KMP2375) is produced in HEK293 Cells and the target gene encoding Met113-Leu261 is expressed.
Molecular Weight 16.19 kDa
Alias Tumor Necrosis Factor Ligand Superfamily Member 5, CD154
Species Human
Host HEK293 Cells
Size 50ug, 100ug, 200ug
Purification Affinity purification
Purity >95% as determined by SDS-PAGE
Endotoxin <1.0 EU/ug determined by the LAL method
Buffer 20mM PB, 200mM NaCl, 0.1mM EDTA, pH7.0
Uniprot A0A0S2Z3C7
SDS-PAGE
Background CD40 Ligand(CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.
Storage Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Note This product is for research use only.