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Service Line：+1-315-239-3085
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Troponin I (TnI) is one of the three subunits that make up the thin filament troponin complex of rhabdomyosin. Cardiac troponin I (CTnI) is a cardiac-specifically expressed regulatory protein that plays a key role in the contraction of the heart by inhibiting the binding of myosin and Actin, which mediates the relaxation of the rhabdomyosin.TnI-cardiac is one of the three genes of the TnI subfamily. This gene encodes the TnI-cardiac muscle protein, which is expressed only in myocardial tissue. Mutations in its gene can cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Numerous studies have shown that cTn levels change in the early stages of acute myocardial infarction (AMI) by a wide range. cTnI is one of the most sensitive and specific serum markers of cardiomyocyte injury.
Molecular structure and characteristics of CTnI
Cardiac troponin (cTnI) consists of 210 amino acids, with a molecular weight of 23.9 and an isoelectric point of 9.87. cTnI, as a protein with an a-helix, has five helical regions in a stretched conformation. cTnI is found in human cardiomyocytes in two forms, cTnI-C-T complex, and free cTnI. cTnI is found as a small portion of soluble protein in the periplasm. free protein; otherwise, most of the cTnI is an insoluble structural protein that is integrated into myofibrils. However, no form of cTnI can pass through the intact myocardial cell membrane and enter the blood circulation, and therefore the amount of cTnI in the blood is extremely low. When the integrity of the cell membrane is damaged by hypoxia and ischemia, free cTnI can quickly penetrate the damaged cell membrane and enter the blood circulation; at the same time, cTnI fixed in myofibers is slowly broken down and becomes free cTnI. cTnI, as a diagnostic marker for acute myocardial infarction, can not only be detected at an early stage but also lasts for a longer period.
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Figure 2 Molecular structure of CTnI
Diseases in which CTnI is involved
|
Disease name |
Abbreviations |
|
Cardiomyopathy, familial hypertrophy, 7 |
* CMH7 |
|
Dilated cardiomyopathy, 2A |
* CMD2A |
|
Cardiomyopathy, familial restrictive, 1 |
* RCM1 |
The inventory of raw materials associated with Cardiac Troponin I that KMD Bioscience can offer:
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CAT# |
Product Name |
Species |
Host |
Application |
Size |
Product Type |
|
PA196 |
Human |
Mouse |
LFIA (Lateral-Flow Immunochromatographic Assay), CLIA (Chemiluminescence Immunoassay), ELISA |
1mg |
Raw Materials |
|
|
PA197 |
Human |
Mouse |
LFIA (Lateral-Flow Immunochromatographic Assay), CLIA (Chemiluminescence Immunoassay), ELISA |
1mg |
Raw Materials |
|
|
SMAG3245 |
Human |
E. coli |
LFIA (Lateral-Flow Immunochromatographic Assay), CLIA (Chemiluminescence Immunoassay), ELISA |
1mg |
Raw Materials |
|
|
PA4255 |
Human |
Rabbit |
WB, IF |
50ul, 100ul |
Research Reagents |
|
|
PA15309 |
Human |
Rabbit |
WB, IF |
50ul, 100ul |
Research Reagents |
KMD Bioscience, as a supplier of in vitro diagnostic raw materials, provides high-quality diagnostic antigen and antibody raw materials for the IVD industry for over several years, which are suitable for a variety of assay platforms, such as flow, colloidal gold, CLIA-Chemiluminescence Immunoassay, Turbidimetric inhibition immunoassay, etc. KMD Bioscience has a monoclonal antibody production. With four platforms, including monoclonal antibody production platform, polyclonal antibody production platform, phage antibody library technology platform, and antibody engineering, KMD Bioscience is committed to the rapid development and large-scale production of proteins and antibodies for in vitro diagnostics. KMD Bioscience's antibody diagnostic raw materials and antigen diagnostic raw materials are strictly monitored during the R&D and production phases, and the performance indexes (specificity, activity, stability, etc.) of antibodies/antigens are analyzed to ensure that IVD raw materials are characterized by small batch-to-batch/intra-batch variations, wide linear ranges, good stability, high sensitivity, and so on. KMD Bioscience can create tailor-made one-stop solutions according to the needs and application scenarios of Scientists around the world, fully supporting the development of in vitro diagnostic reagent products.
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com