KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Heart-fatty acid binding protein (H-FABP), also known as FABP3, is a novel small cytoplasmic protein found in cardiomyocytes, with a molecular weight of 15KD and relative specificity for cardiomyocytes. As a major isoform present in cardiac and skeletal muscle, it is specifically present in cardiac tissue, as well as in red skeletal muscle, smooth muscle cells of the aortic wall, endothelial cells, mural cells of gastric glands, and testicular mesenchymal cells, and to a lesser extent in kidney, white skeletal muscle, adrenal glands, and brain; however, there is no distribution of H-FABP in the liver or adipose tissue. Cardiac-type fatty acid-binding proteins account for approximately 4%-8% of all soluble proteins in the heart, and most are cleared by the kidneys. H-FABP plays a key role in mitochondrial β-oxidation by partitioning long-chain fatty acids to the mitochondria. The H-FABP gene is located on chromosome 1 of the human genome, and this is a quantitative trait locus implicated in hypertension, the activation of which is controlled by the sympathetic nervous system. Following myocardial necrosis, H-FABP is rapidly released from the myocardium into the circulation and is detected in the periphery, and has therefore been investigated for use as a biomarker of acute myocardial infarction (AMI). And the sensitivity and specificity are between CTnI and MYO.
Molecular structure of H-FABP:
Fatty acid binding proteins (FABP) are one of the families of proteins that reflect tissue damage. These 14-15 kDa low molecular weight proteins are abundantly present in cytoplasmic solutes and are involved in the binding and transport of long-chain fatty acids. It is a family of homologous small-molecule intracellular proteins, and at least nine types of FABP have been found to exist: hepatic (L, Z-protein, FABP1), intestinal (I, FABP2), cardiac (H, FABP3), adipocytotic (A, FABP4), cerebral (B, FABP6), ileocecal (I1), epithelial (E, PABP5), myelophospholipid type (My, MP2), and testicular type, and named after the first tissue isolated and identified. The amino acid sequences of the different types of FABP have 38%-70% homology, and in the spatial structure, there are two α-helices and one β2-folded structure, which form a clamshell-like shape, whose inner lumen can hold fatty acids, increase stability by certain flexure, and protect fatty acids independently from its external environment.
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Figure 1 Schematic diagram of H-FABP molecular structure
Biological functions of H-FABP
Heart-fatty acid binding protein (H-FABP) is a 132-amino acid protein encoded by the FABP3 gene located on human chromosome 1. H-FABP is a novel small cytoplasmic protein enriched in the heart with a high degree of specificity and is expressed in the heart at a concentration 10 times that of skeletal muscle. Under normal conditions, H-FABP is abundantly present in cardiomyocytes and plays an important role in fatty acid metabolism in the normal heart. When cardiomyocyte damage occurs, there is a rapid influx into the bloodstream, which causes a rapid increase in the activity of serum H-FABP, which is finally excreted from the body through the urine. And when the cardiomyocytes are no longer damaged, the concentration of H-FABP will drop rapidly. It is a new type of biomarker that reflects myocardial damage at an early stage.
The inventory of reagents associated with Heart-fatty acid binding protein (H-FABP) that KMD Bioscience can offer:
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CAT# |
Product Name |
Species |
Host |
Application |
Size |
Product Type |
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PA200 |
Human |
Mouse |
LFIA (Lateral-Flow Immunochromatographic Assay), CLIA (Chemiluminescence Immunoassay), ELISA |
1mg |
Raw Materials |
|
|
PA201 |
Human |
Mouse |
LFIA (Lateral-Flow Immunochromatographic Assay), CLIA (Chemiluminescence Immunoassay), ELISA |
1mg |
Raw Materials |
|
|
SMAG3246 |
Human |
E. coli |
LFIA (Lateral-Flow Immunochromatographic Assay), CLIA (Chemiluminescence Immunoassay), ELISA |
1mg |
Raw Materials |
|
|
PA13947 |
Human |
Rabbit |
WB, IHC, IF |
50ul, 100ul |
Research Reagents |
|
|
MA1323 |
Human |
Rabbit |
WB, IF |
50ul, 100ul |
Research Reagents |
|
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KMP4052 |
Mouse |
E. coli |
|
50ug, 100ug, 200ug |
Research Reagents |
As a supplier of antigen and antibody raw materials, KMD Bioscience develops high-quality diagnostic raw materials and reagents through long-term and dedicated research on diseases and disease markers. Its products cover almost the whole field of immunodiagnostics, mainly used in myocardial, oncology, autoimmune diseases, thyroid gonadal, infectious diseases, thrombosis, etc., and can provide supporting quality control serum and hormone removal serum. KMD Bioscience is committed to providing improved solutions for the in vitro diagnostics industry, with product lines spanning multiple sectors, serving both industrial and research customers.
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com