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Recombinant Human CD80 Protein, His Tag

Product Information
Catalog Number KMH245
Product Name Recombinant Human CD80 Protein, His Tag
Product Description Recombinant Human CD80 Protein, His Tag (KMH245) contains the human CD80(Met1-Asn242) was fused with the C-terminal His Tag and expressed in Mammalian cells.
Molecular Name CD80
Uniprot ID P33681
Alias B7, BB1, B7 1, B7.1, LAB7, CD28LG, CD28LG1, CD80 molecule
Protein Family CD molecule
Size 50ug, 100ug
Species Human
Host Mammalian cells
Molecular Weight 28.52 kDa
Purity ≥90% as determined by SDS-PAGE
Endotoxin < 1.0 EU per ug of the protein as determined by the LAL method.
Cross-Reactivity No cross-reactivity with other antigens or proteins.
Buffer PBS, pH7.5
Purification Affinity Purification
Background It is widely accepted that T cells require a signal induced by the engagement of the T cell receptor and a "costimulatory" signal(s) through distinct T cell surface molecules for optimal T cell expansion and activation. Members of the B7 superfamily of counterreceptors were identified by their ability to interact with costimulatory molecules found on the surface of T cells. Members of the B7 superfamily include B7-1 (CD8), B7-2 (CD86), B7-H1 (PD-L1), B7-H2 (B7RP-1), B7-H3 and PD-L2. B7-1 is expressed on activated B cells, activated T cells, mature dendritic cells and macrophages. T cells express two different receptors capable of binding B7-1, CD28 and CTLA-4. CTLA-4 binds to B7-1 with a 2 - 1 fold higher affinity than CD28. Engagement of CD28 by B7-1 increases T cell proliferation and IL-2 production and enhances the immune response. In contrast, engagement of CTLA-4 is involved in the down-regulation of the immune response. Rat and human B7-1 share 47% amino acid identity.
Storage Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.