KMD Bioscience Co., Ltd.
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Email：info@kmdbioscience.com
| Catalog Number | KMP2398 |
|---|---|
| Product Name | Mouse CD80 Protein, Fc Tag |
| Product Description | The Mouse CD80 Protein(KMP2398) is produced in HEK293 Cells and the target gene encoding Val38-Lys245 is expressed with a Fc tag at the C-terminus. |
| Molecular Weight | 23.69 kDa |
| Alias | T-lymphocyte activation antigen CD80, Activation B7-1 antigen |
| Species | Mouse |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purification | Affinity purification |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Uniprot | Q3U4B5 |
| SDS-PAGE |  |
| Background | Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. Studies have shown that CTLA-4 binds mostly to CD80. The structure presents two extracellular domains: a membrane distal variable-like domain(IgV) and a membrane proximal Ig constant-like domain(IgC) along with an intracellular domain. Both IgV and IgC consist of anti-parallel beta sandwiches joined by a short linker region. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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