KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+86-022-82164980
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：[email protected]
| Catalog Number | PM1002 |
|---|---|
| Product Name | Cluster of differentiation 80 |
| Alias | B7-1; B7.1; CD28LG; CD28LG1; LAB7 |
| Size | 100ul |
| Immunogen | The product is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to residues of human CD80. |
| Product Description | PM1002, Cluster of differentiation 80 is a molecule found on activated B cells and monocytes. After engagement of T-cell receptor with antigen in association with major histocompatibility complex class II, a second signal mediated through the binding of B7 to CD28 greatly upregulates the production of multiple lymphokines. B7-1 is a costimulatory molecule for the activation of both CD4+ and CD8+ T lymphocytes that prevents the induction of clonal anergy. Thus, the transfer of B7-1 genes into tumor cells can induce protective immunity and lead to tumor rejection of some tumors in model systems of in vivo tumor growth. |
| Species | Human, Mouse |
| Host | Rabbits |
| Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Purification | Immunogen affinity purified |
| Background | CD80 can be found on the surface of various immune cells including dendritic cells, B cells, monocytes and antigen-presenting cells (APCs) and is the receptor for the proteins CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) found on the surface of T-cells. |
| Storage | For longer term storage -20°C. Aliquot to avoid multiple freeze/thaw cycles. |
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：[email protected]
Hot Line： +86-022-82164980
Technical Support：[email protected]
