KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+86-022-82164980
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：[email protected]
| Catalog Number | KMH513 |
|---|---|
| Product Name | Recombinant Human HAVCR2 Protein, His Tag |
| Product Description | Recombinant Human HAVCR2 Protein, His Tag (KMH513) contains the human HAVCR2(Met1-Arg200) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
| Molecular Name | HAVCR2 |
| Uniprot ID | Q8TDQ0 |
| Alias | TIM3, CD366, KIM 3, SPTCL, TIMD3, Tim 3, TIMD 3, HAVcr 2, hepatitis A virus cellular receptor 2 |
| Protein Family | Antibody drug target protein |
| Size | 50ug, 100ug |
| Species | Human |
| Host | Mammalian cells |
| Molecular Weight | 20.67 kDa |
| Purity | ≥90% as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU per ug of the protein as determined by the LAL method. |
| Cross-Reactivity | No cross-reactivity with other antigens or proteins. |
| Buffer | Supplied as solution form in 50 mM Tris-HCl, pH 8.0, 150 mM NaCl./Lyophilized from 50 mM Tris-HCl, pH 8.0, 150 mM NaCl. |
| Purification | Affinity Purification |
| Background | Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFNgamma secretion and influences the ability to induce T cell tolerance in both mice and man. |
| Storage | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：[email protected]
Hot Line： +86-022-82164980
Technical Support：[email protected]
