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| Catalog Number | KMP2399 |
|---|---|
| Product Name | Cynomolgus HAVCR2 Protein, His Tag |
| Product Description | The Cynomolgus HAVCR2 Protein(KMP2399) is produced in HEK293 Cells and the target gene encoding Ser22-Arg201 is expressed with a 8His tag at the N-terminus. |
| Molecular Weight | 20.46 kDa |
| Alias | Hepatitis A virus cellular receptor 2, HAVCR2 |
| Species | Cynomolgus |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purification | Affinity purification |
| Purity | >95% as determined by SDS-PAGE |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Buffer | PBS, pH7.4 |
| Uniprot | A0A2K5U3G7 |
| SDS-PAGE |  |
| Background | T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid(aa)extracellular domain(ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells(macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells(Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity. |
| Storage | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Note | This product is for research use only. |
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