Human LAG3 Protein, hFc Tag

Product Information

Catalog Number	KMP3380
Product Name	Human LAG3 Protein, hFc Tag
Product Description	The Human LAG3 Protein(KMP3380) is produced in HEK293 Cells. The target gene encoding the human LAG3 (NP_002277.4) (Met1-Leu450) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	LAG3
Alias	Human LAG3 Protein, hFc Tag, LAG3
Molecular Weight	72.9 kDa
Species	Human
Size	50ug, 100ug, 200ug
Host	HEK293 Cells
Purity	>95% as determined by SDS-PAGE
Endotoxin	<1.0 EU/ug determined by the LAL method
Buffer	20mM NaH2PO4, 150mM NaCl, 0.1M Arg, 0.1M Glu, 10% Glycerol, 0.01% Tween20, pH7.4
Purification	Affinity purification
Background	LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.
Storage	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Note	This product is for research use only.

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