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Cynomolgus LAG3 Protein, His Tag

Product Information
Catalog Number KMP3694
Product Name Cynomolgus LAG3 Protein, His Tag
Product Description The Cynomolgus LAG3 Protein(KMP3694) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus LAG3 (XP_005570011.1) (Met1-Leu450, 74 Pro) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name LAG3
Alias LAG3 Protein, Cynomolgus LAG3 Protein, His Tag
Size 50ug, 100ug, 200ug
Species Cynomolgus
Host HEK293 Cells
Purity >95% as determined by SDS-PAGE
Endotoxin <1.0 EU/ug determined by the LAL method
Buffer PBS, pH7.4
Purification Affinity purification
Molecular Weight 47.4 kDa
Background LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.
Storage Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Note This product is for research use only.