KMD Bioscience Co., Ltd.
400-621-6806
Service Line：+1-315-239-3085
Address：FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
KMD Bioscience is a professional provider of preclinical CRO services with a team of highly skilled scientists to provide our clients with a rapid and high throughput drug target screening platform. We supply a wide range of compound library screening services to major research institutes and pharmaceutical companies. Our clients simply provide us with their compound libraries and we screen potential compounds using standard experimental procedures.
Transport proteins are the largest family of membrane proteins in human organisms and include members of the solute carrier transport protein and ATP-binding cassette transport protein families. They play a key role in the absorption, distribution and excretion of exogenous and endogenous molecules. Transport proteins are widely expressed in a variety of human tissues and are routinely evaluated during drug development and approval. Transport proteins are currently being used as therapeutic targets for the treatment of diabetes, major depressive disorder, hypertension, constipation and many other diseases. Little is known about the endogenous substrates or physiological functions of more than half of the members of the transport protein superfamily, despite the steady growth in the field of transport protein biology.
KMD Bioscience offers a dedicated transport protein panel and a customized transport protein screening service to enable you to identify new transport protein target compounds. Our panel of transport proteins includes the FDA transport protein screening panel, the monoamine transport protein model and many other cellular models. We use robust transport protein uptake and inhibition assays to screen New Molecular Entities (NME) quickly and efficiently, providing you with results with high-confidence background ratios and Z-scores.
Service Content:
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P-gp Inhibitor Screening |
SLC Transporter Substrate Identification（OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, OATP1A2, OATP2B1, OAT2, OAT4, OCTN2, PEPT1, PEPT2, NTCP） |
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BCRP Substrate Identification |
SLC Transport Protein Inhibition（OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, OATP1A2, OATP2B1, OAT2, OAT4, OCTN2, PEPT1, PEPT2, NTCP） |
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BCRP Inhibitor Screening |
BSEP Inhibition |
Other transport protein assays are available on request.
Customer Provides:
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Compounds |
Targets |
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Bioinformatics and pharmacological information |
Target protein or peptide |
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Structural classification (e.g. flavonoids, alkaloids, etc.) |
Purity >90%, concentration 1mg/ml |
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Solubility information |
Produced and prepared by KMD Bioscience based on target sequences provided by the customer |
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Signaling pathways or targets, etc. |
For more information, please visit Protein Platform |
Cell lines: KMD Bioscience provides overexpression cell line construction service. For more information, please visit IOS overexpression stable cell line construction service.
Service Highlights:
--Cell-based assays provide functional characterization of compound activity
--Multiple service offerings
--Short cycle times
--Customized project solutions
How to Order?
If you have any questions regarding our services or products, please feel free to contact us by E-mail: info@kmdbioscience.com or Tel: +86-400-621-6806
FL-4, Building A5, International Enterprise Community, Tianjin, China
Email：info@kmdbioscience.com
Hot Line： +1-315-239-3085
Technical Support：sales@kmdbiosci.com