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Recombinant Human EGFR Protein, His tag

Product Information
Catalog Number KMH495
Product Name Recombinant Human EGFR Protein, His tag
Product Description Recombinant Human EGFR Protein, His tag (KMH495) contains the human EGFR(Met1-Ser645) was fused with the C-terminal His Tag and expressed in Mammalian cells.
Molecular Name EGFR
Uniprot ID P00533
Alias ERBB, HER1, mENA, ERBB1, PIG61, NISBD2, epidermal growth factor receptor
Protein Family Antibody drug target protein
Size 50ug, 100ug
Species Human
Host Mammalian cells
Molecular Weight 70.95 kDa
Purity ≥90% as determined by SDS-PAGE
Endotoxin < 1.0 EU per ug of the protein as determined by the LAL method.
Cross-Reactivity No cross-reactivity with other antigens or proteins.
Buffer PBS, pH7.5
Purification Affinity Purification
Background As a member of the epidermal growth factor receptor tyrosine kinases subfamily, EGF R is a type Ⅰ transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR signaling plays a crucial role in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR homo- or hetero- dimerization, initiates subsequent tyrosine autophosphorylation and various downstream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling has been shown to exert actions on carcinogenesis and disease progression, and thus EGFR was proposed as a target for cancer therapy currently.
Storage Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
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