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Human EGFR Protein, Fc Tag

Product Information
Catalog Number KMPH1101
Product Name Human EGFR Protein, Fc Tag
Alias Egfr, epidermal growth factor receptor, EGFR, ERBB, ERBB1, HER1, PIG61, mENA
Size 50ug, 100ug
Species Human
Host HEK293 Cells
Source This protein contains (Met 1-Gly 645) of human EGFR (NP_005219) was fused with the Fc region of human IgG1 at the C-terminus and expressed from HEK293 Cells.
Purity >97%, determined by SDS-PAGE
Endotoxin <1.0 EU/ug determined by the LAL method
Cross-Reactivity No cross-reactivity with other antigens or proteins.
Buffer Lyophilized from sterile 20mM Tris, 50mM NaCl, 3mM DTT, 0.5mM TCEP, pH 7.4, and 0.01% Tween80 are added as protectants
Background As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
Storage Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
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