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Human EGFR Protein, hFc Tag

Product Information
Catalog Number KMP3473
Product Name Human EGFR Protein, hFc Tag
Product Description The Human EGFR Protein(KMP3473) is produced in Insect Cells. The target gene encoding the human EGFR (NP_001333870.1) (Met1-Lys375) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name EGFR
Alias Human EGFR Protein, hFc Tag, EGFR
Molecular Weight 65.1 kDa
Species Human
Size 50ug, 100ug, 200ug
Host Insect Cells
Purity >95% as determined by SDS-PAGE
Endotoxin <1.0 EU/ug determined by the LAL method
Buffer 100mM Glycerolcine, 10mM NaCl, pH7.4
Purification Affinity purification
Background As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
Storage Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Note This product is for research use only.
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