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Human EGFR Protein, His Tag, Avi Tag

Product Information
Catalog Number KMP2436
Product Name Human EGFR Protein, His Tag, Avi Tag
Product Description The Human EGFR Protein(KMP2436) is produced in HEK293 Cells. The target gene encoding the human EGFR (NP_005219.2) (Met1-Ser645) is expressed with a c-terminal polyhistidine tagged Avi tag at the C-terminus. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name EGFR
Alias Human EGFR Protein, His Tag, Avi Tag, EGFR
Molecular Weight 71.9 kDa
Species Human
Size 50ug, 100ug, 200ug
Host HEK293 Cells
Purity >95% as determined by SDS-PAGE
Endotoxin <1.0 EU/ug determined by the LAL method
Buffer PBS, pH7.4
Purification Affinity purification
Background As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
Storage Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Note This product is for research use only.
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