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Feline EGFR Protein, His Tag

Product Information
Catalog Number KMP3789
Product Name Feline EGFR Protein, His Tag
Product Description The Feline EGFR Protein(KMP3789) is produced in Insect Cells. A DNA sequence encoding the feline EGFR (A0A337S424) (Leu25-Ser645) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name EGFR
Alias EGFR Protein, Feline EGFR Protein, His Tag
Size 50ug, 100ug, 200ug
Species Feline
Host Insect Cells
Purity >95% as determined by SDS-PAGE
Endotoxin <1.0 EU/ug determined by the LAL method
Buffer 20mM Tris, 300mM NaCl, 10% Glycerol, pH8.0
Purification Affinity purification
Molecular Weight 70.18 kDa
Background As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
Storage Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Note This product is for research use only.
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