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CD274/PD-L1 Target

2024-03-15 Hits(403)

The CD274 gene (Gene ID:29126), also known as programmed death ligand 1 (PD-L1) or B7 homologue 1 (B7-H1), is critical in immunoregulatory responses. It encodes a type I transmembrane protein weighing 40 kDa, PD-L1, which plays an important role in suppressing the adaptive immune system during pregnancy, tissue allografts, autoimmune disorders, and hepatitis, among other conditions. PD-L1 was initially characterized as an immunomodulatory molecule in 1999 at the Mayo Clinic. Due to its ability to aid tumor cells in evading antitumor immunity, it has been identified as a cancer-associated factor. PD-L1 interacts with its receptor, PD-1, and is expressed on activated T cells, B cells, and myeloid cells to regulate their activation or suppression. This interaction inhibits T-cell receptor (TCR)-mediated activation of IL-2 production and T-cell proliferation and plays a key role in immune response regulation.

The expression of PD-L1 is influenced by interferons. For example, IFN-γ induces the expression of PD-L1 in a variety of cell types, including T cells, NK cells, macrophages, and epithelial cells. The PD-L1 gene promoter contains a response element for the interferon regulatory factor IRF-1, highlighting the regulation of the gene by immune signaling.

Interestingly, the expression of PD-L1 varies across cell types and under different conditions. For example, it is significantly expressed on macrophages and its expression is influenced by factors such as LPS and interferon-γ. This expression is regulated by components such as STAT1 and can exhibit variability based on the activation status of the macrophage.

KMD Bioscience is an innovative biotechnology company dedicated to providing high-quality CD274/PD-L1 proteins, CD274/PD-L1 antibodies and other high-quality targeting products to research institutions, universities and companies. Always adhering to the principle of customer first, KMD Bioscience is committed to providing the best quality CD274/PD-L1 related products and promoting the continuous innovation and development in the field of biotechnology.

The featured target CD274/PD-L1 protein products launched by KMD Bioscience:

CAT#	Products Name	Specise	Host	Size	Inquiry
KMPH1193	Human PDL1/CD274/PDL1 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH1194	Human CD274/PDL1 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH1195	Human CD274/PDL1 Protein, His Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
MOP1030	Mouse CD274/PDL1 Protein, His & Fc Tag	Mouse	HEK293 Cells	100ug, 200ug	Inquiry
MOP1031	Mouse CD274/PDL1 Protein, His Tag	Mouse	HEK293 Cells	100ug, 200ug	Inquiry
PM299	Cynomolgus CD274/PDL1 Protein, Fc Tag	Cynomolgus	HEK293 Cells	100ug, 200ug	Inquiry
PM300	Cynomolgus CD274/PDL1 Protein, His Tag	Cynomolgus	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5881	Human CD274/PDL1 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5882	Human CD274/PDL1 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5883	Human CD274/PDL1 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5884	Human CD274/PDL1 Protein, Strep Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5885	Human CD274/PDL1 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5886	Human CD274/PDL1 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5887	Human CD274/PDL1 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5888	Human CD274/PDL1 Protein, His & Fc & Avi Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5889	Human CD274/PDL1 Protein, Fc & Avi Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5890	Human CD274/PDL1 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5891	Human CD274/PDL1 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5892	Human CD274/PDL1 Protein, Avi Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5929	Human CD274/PDL1 Protein, His & Fc & Avi Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5930	Human CD274/PDL1 Protein, Fc & Avi Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5931	Human CD274/PDL1 Protein, Avi Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH6573	Human CD274/PDL1 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMH423	Recombinant Human CD274 Protein, His Tag	Human	Mammalian cells	50ug, 100ug	Inquiry
MOP2061	Recombinant Mouse Cd274/Pdl1/B7h1 Protein, His Tag	Mouse	Mammalian cells	50ug, 100ug	Inquiry
KMH718	Recombinant Human B7-H1/PD-L1/CD274 Protein, Fc Tag	Human	Mammalian cells	50ug, 100ug	Inquiry
KMH719	Recombinant Human B7-H1/PD-L1/CD274 Protein, His Tag	Human	Mammalian cells	50ug, 100ug	Inquiry
KMH1532	Recombinant Human PD-L1/B7-H1/CD274 Protein, Fc Tag	Human	Mammalian cells	50ug, 100ug	Inquiry

The featured target CD274/PD-L1 antibody products launched by KMD Bioscience:

CAT#	Products Name	Specise	Host	Appliance	Size	Inquiry
PA5389	Rabbit Anti-Human CD274 pAb	Human	Rabbit	WB, IHC, IF	50ul, 100ul	Inquiry
PA10143	Rabbit Anti-Human CD274 pAb	Human	Rabbit	WB, IHC, IF	50ul, 100ul	Inquiry

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CD274/PD-L1 Target