KMD Bioscience Co., Ltd.
400-621-6806
2024-02-26 Hits(380)
CD80 (Gene ID:941), also known as B7-1 or CD28 ligand, is a cell surface protein encoded by the CD80 gene, which is a member of the B7 family of immune checkpoint molecules that play a key role in the regulation of immune responses. In the early 1990s, CD80 was identified as a molecule that is expressed on the surfaces of antigen-presenting cells (APCs), such as dendritic cells, macrophages, and B cells. It interacts with the receptors CD28 and CTLA-4 (CD152) on T cells to regulate T cell activation and differentiation. CD80 is a key co-stimulatory molecule that interacts with CD28 on T cells. This interaction provides a second signal during T-cell activation, as well as T-cell receptor (TCR) signaling. Binding of CD80 to CD28 enhances T-cell proliferation, cytokine production, and effector function, thereby ensuring an effective immune response. CD80 also plays a role in immune tolerance. When T cells encounter APCs expressing CD80 without sufficient activation of the TCR, it can result in either unresponsiveness (unresponsive state) or induction of regulatory T cell (Tregs). These mechanisms effectively prevent undesired immune responses to self-antigens. Moreover, CD80 exhibits a dual role in immunoregulation. Although it provides co-stimulation through CD28, it can also interact with the inhibitory receptor CTLA-4 (CD152) on activated T cells. By competing with CD28 for binding to CD80, CTLA-4 inhibits T cell activation and contributing to immune homeostasis.
KMD Bioscience is an innovative biotechnology company dedicated to providing high-quality CD80/B7-1 protein, CD80/B7-1 antibody and other high-quality target products for research institutions, universities and companies. Adhering to the principle of customer first, KMD Bioscience is committed to providing the best quality CD80/B7-1 related products and promoting the continuous innovation and development in the field of biotechnology.
The featured target CD80/B7-1 protein products launched by KMD Bioscience:
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CAT# |
Products Name |
Species |
Host |
Size |
Inquiry |
|
KMPH2276 |
Human |
HEK293 Cells |
100ug, 200ug |
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KMPH2277 |
Human |
HEK293 Cells |
100ug, 200ug |
||
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KMPH2278 |
Human |
HEK293 Cells |
100ug, 200ug |
||
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MOP1340 |
Mouse |
HEK293 Cells |
100ug, 200ug |
||
|
MOP1341 |
Mouse |
HEK293 Cells |
100ug, 200ug |
||
|
PM305 |
Cynomolgus |
HEK293 Cells |
100ug, 200ug |
||
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KMPH5799 |
Human |
HEK293 Cells |
100ug, 200ug |
||
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KMPH5800 |
Human |
HEK293 Cells |
100ug, 200ug |
||
|
KMPH5801 |
Human |
HEK293 Cells |
100ug, 200ug |
||
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KMPH5802 |
Human |
HEK293 Cells |
100ug, 200ug |
||
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KMPH5803 |
Human |
HEK293 Cells |
100ug, 200ug |
||
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KMH245 |
Human |
Mammalian cells |
50ug, 100ug |
||
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MOP2071 |
Mouse |
Mammalian cells |
50ug, 100ug |
||
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MOP2072 |
Mouse |
Mammalian cells |
50ug, 100ug |
||
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PO123 |
Rabbit |
Mammalian cells |
50ug, 100ug |
||
|
PO124 |
Rat |
Mammalian cells |
50ug, 100ug |
||
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KMP2331 |
Rabbit |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2332 |
Rat |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2333 |
Mouse |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2334 |
Cynomolgus |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2338 |
Human |
HEK293 Cells |
50ug, 100ug, 200ug |
||
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KMP2398 |
Mouse |
HEK293 Cells |
50ug, 100ug, 200ug |
The featured target CD80/B7-1 antibody products launched by KMD Bioscience:
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CAT# |
Products Name |
Species |
Host |
Appliance |
Size |
Inquiry |
|
PM1002 |
Human, Mouse |
Rabbits |
FC , ICC , IHC , WB |
100ul |
||
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PA9713 |
Human |
Rabbit |
WB, IF |
50ul, 100ul |
||
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MA508 |
Human |
Rabbit |
WB |
50ul, 100ul |
Other advantageous products from KMD Bioscience:
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