KMD Bioscience Co., Ltd.
400-621-6806
2024-03-15 Hits(408)
CD47 (Gene ID:961) was initially discovered in the early 1990s as an antigen expressed on human erythrocytes. It is a member of the immunoglobulin superfamily and is known for its interaction with signal regulatory protein alpha (SIRPα) and platelet response protein-1 (TSP-1). Subsequently, CD47 has been acknowledged as a key player in the "don't eat me" signaling pathway, which inhibits macrophages from engulfing healthy cells. The main functions of CD47 are as follows:
1. CD47 acts as a "don't eat me" signal by binding to SIRPα on macrophages, thereby initiating an inhibitory signal to macrophages, preventing them from engulfing and destroying CD47-expressing cells. This mechanism is essential to avoid immune clearance of healthy cells.
2. CD47 plays a role in maintaining tissue homeostasis by inhibiting the phagocytosis of senescent or damaged cells, thereby preserving the integrity of various tissues and organs .
3. CD47 helps regulate angiogenesis, the process of new blood vessel formation. Depending on the environment, its interaction with TSP-1 can either promote or inhibit angiogenesis.
4. Many cancer cells upregulate CD47 as a strategy to evade the immune system. Elevated expression of CD47 on cancer cells can inhibit macrophage-mediated phagocytosis, allowing tumors to evade immune surveillance.
KMD Bioscience is an innovative biotechnology company dedicated to providing high-quality CD47 protein, CD47 antibody and other high-quality target products to research institutions, universities and companies. Adhering to the principle of customer first, KMD Bioscience is committed to providing the best quality CD47 related products and promoting the continuous innovation and development in the field of biotechnology.
The featured target CD47 protein products launched by KMD Bioscience:
|
CAT# |
Products Name |
Specise |
Host |
Size |
Inquiry |
|
KMPH3540 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH3541 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
MOP1909 |
Mouse |
HEK293 Cells |
50ug, 200ug |
||
|
PR109 |
Rat |
HEK293 Cells |
50ug, 200ug |
||
|
PR110 |
Rat |
HEK293 Cells |
50ug, 200ug |
||
|
MOP1980 |
Mouse |
|
50ug, 200ug |
||
|
MOP1981 |
Mouse |
|
50ug, 200ug |
||
|
MOP1982 |
Mouse |
|
50ug, 200ug |
||
|
MOP1983 |
Mouse |
|
50ug, 200ug |
||
|
KMH205 |
Human |
Mammalian cells |
50ug, 100ug |
||
|
KMP3003 |
Human |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP3004 |
Human |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP3005 |
Human |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP3006 |
Human |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2237 |
Rhesus Macaque |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2289 |
Human |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2305 |
Human |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2317 |
Mouse |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2353 |
Mouse |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2379 |
Human |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP2403 |
Human |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP3771 |
Cynomolgus |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP4104 |
Mouse |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP4105 |
Mouse |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP4106 |
Mouse |
HEK293 Cells |
50ug, 100ug, 200ug |
||
|
KMP4360 |
Rhesus |
HEK293 Cells |
50ug, 100ug, 200ug |
The featured target CD47 antibody products launched by KMD Bioscience:
|
CAT# |
Products Name |
Specise |
Host |
Appliance |
Size |
Inquiry |
|
PA11800 |
Human |
Rabbit |
WB, IHC, IF |
50ul, 100ul |
||
|
PA15561 |
Human |
Rabbit |
WB, IHC, IF |
50ul, 100ul |
||
|
MA326 |
Human |
Rabbit |
WB, IHC |
50ul, 100ul |
Other advantageous products from KMD Bioscience:
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