KMD Bioscience Co., Ltd.
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2024-03-15 Hits(359)
VTCN1 (V-Set structural domain-containing T cell activation inhibitory factor 1), also known as B7-H4 (Gene ID: 79679), is a gene that encodes a cell surface protein belonging to the B7 family of immune checkpoint molecules. VTCN1 plays a role in the regulation of immune responses and has been associated with immune tolerance. Initially identified as a member of the B7 family, which includes well-known immune checkpoint molecules such as PD-1 and CTLA-4. VTCN1 was initially characterized for its role in inhibiting T-cell activation, but further studies revealed its importance in immune regulation and its significance in cancer and autoimmune diseases. The main functions of VTCN1 are as follows.
1. Immune checkpoint: VTCN1 is mainly expressed on antigen-presenting cells (APCs) and certain tumor cells. It interacts with receptors on T cells, leading to inhibitory signaling pathways. The binding of VTCN1 to its receptors inhibits T cell activation and proliferation, contributing to immunosuppression and tolerance.
2. Immune tolerance: The role of VTCN1 as an immune checkpoint is believed to be crucial in maintaining immune tolerance and preventing excessive immune responses towards self-antigens or harmless microorganisms. Dysregulation of VTCN1 signaling can lead to autoimmune diseases.
3. Tumor immunity: The expression of VTCN1 on tumor cells inhibits anti-tumor immune responses, thereby facilitating immune evasion, promoting tumor growth and metastasis. Targeting VTCN1 has been investigated as a potential immunotherapeutic strategy to augment anti-tumor immunity.
KMD Bioscience is an innovative biotechnology company dedicated to providing high-quality VTCN1/B7-H4 protein, VTCN1/B7-H4 antibody and other high-quality targeting products to research institutions, universities and companies. Adhering to the principle of customer first, KMD Bioscience is committed to providing the best quality VTCN1/B7-H4 related products and promoting the continuous innovation and development in the field of biotechnology.
The featured target VTCN1/B7-H4 protein products launched by KMD Bioscience:
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CAT# |
Products Name |
Specise |
Host |
Size |
Inquiry |
|
KMPH2312 |
Human |
HEK293 Cells |
50ug, 100ug |
||
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KMPH2313 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
MOP1037 |
Mouse |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5810 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMPH5811 |
Human |
HEK293 Cells |
50ug, 100ug |
||
|
KMH516 |
Human |
Mammalian cells |
50ug, 100ug |
||
|
MOP2077 |
Mouse |
Mammalian cells |
50ug, 100ug |
||
|
KMP2293 |
Rhesus Macaque |
HEK293 Cells |
50ug, 100ug, 200ug |
||
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KMP2324 |
Mouse |
HEK293 Cells |
50ug, 100ug, 200ug |
The featured target VTCN1/B7-H4 antibody products launched by KMD Bioscience:
|
CAT# |
Products Name |
Specise |
Host |
Appliance |
Size |
Inquiry |
|
PA5012 |
Human |
Rabbit |
WB |
50ul, 100ul |
Other advantageous products from KMD Bioscience:
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