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CD28 Target

Discovered in the early 1980s, CD28 (Gene ID:940) was among the pioneering co-stimulatory molecules identified in the immune system. It is a member of the immunoglobulin superfamily and is expressed predominantly on the surface of CD4+ and CD8+ T cells. CD28 is a receptor for CD80 (B7-1) and CD86 (B7-2), which are expressed on antigen-presenting cells (APCs), such as dendritic cells, macrophages, and B cells. The interaction between CD28 and these ligands provide a critical second signal for T cell activation.

CD28 is a key co-stimulatory receptor protein expressed primarily on the surface of T cells and plays a critical role in the regulation of adaptive immune responses. The gene is located on chromosome 2q33.2 and is essential for T cell activation and immune cell interactions. The gene functions of CD28 are as follows.

1. T cell activation: The binding of CD28 to CD80 or CD86 on APCs provides a co-stimulatory signal that enhances the activation of T cell. This signaling is indispensable for complete activation of the initial T cells, as activation of the T cell receptor (TCR) alone is usually insufficient to initiate a robust immune response.

2. Cytokine production: The signaling of CD28 plays a key role in the production of a variety of cytokines, including interleukin-2 (IL-2), which is essential for T cell proliferation and effector function. IL-2 promotes the expansion of antigen-specific T cell populations.

3. T cell differentiation: The signaling of CD28 affects T cell differentiation and promotes the development of effector T cells with specific functions, such as cytotoxic T cells, helper T cells and memory T cells.

KMD Bioscience is an innovative biotechnology company dedicated to providing high-quality CD28 protein, CD28 antibody and other high-quality target products for research institutions, universities and companies. Adhering to the principle of customer first, KMD Bioscience is committed to providing the best quality CD28 related products and promoting the continuous innovation and development in the field of biotechnology.

The featured target CD28 protein products launched by KMD Bioscience:

CAT#	Products Name	Specise	Host	Size	Inquiry
KMPH3235	Human CD28/Tp44 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH3236	Human CD28/Tp44 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
MOP1121	Mouse CD28/Tp44 Protein, Fc & His Tag	Mouse	HEK293 Cells	100ug, 200ug	Inquiry
MOP1122	Mouse CD28/Tp44 Protein, His Tag	Mouse	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5816	Human CD28/Tp44 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5817	Human CD28/Tp44 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMPH5818	Human CD28/Tp44 Protein, Fc Tag	Human	HEK293 Cells	100ug, 200ug	Inquiry
KMH183	Recombinant Human CD28 Protein, Fc Tag	Human	Mammalian cells	50ug, 100ug	Inquiry
KMP2892	Human CD28 Protein, mFc Tag	Human	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP2893	Human CD28 Protein, hFc Tag, Avi Tag	Human	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP2894	Human CD28 Protein, His Tag, Avi Tag	Human	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP3111	Human CD28H Protein, hFc Tag	Human	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP3112	Human CD28H Protein, His Tag	Human	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP3113	Human CD28H Protein, His Tag, Avi Tag	Human	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP3533	Human CD28 Protein, His Tag	Human	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP2236	Human Biotinylated CD28 Protein, Fc Tag, Avi Tag	Human	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP2267	Human CD28 Protein, His Tag	Human	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP2290	Human CD28 Protein, mFc Tag	Human	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP2374	Mouse CD28 Protein, Fc Tag, His Tag	Mouse	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP2380	Human CD28 Protein, Fc Tag	Human	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP3667	Cynomolgus CD28 Protein, hFc Tag	Cynomolgus	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP3800	Cynomolgus CD28 Protein, mFc Tag	Cynomolgus	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP3801	Cynomolgus CD28 Protein, His Tag, Avi Tag	Cynomolgus	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP3803	Cynomolgus CD28 Protein, His Tag	Cynomolgus	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP3841	Mouse CD28 Protein, hFc Tag	Mouse	HEK293 Cells	50ug, 100ug, 200ug	Inquiry
KMP3842	Mouse CD28 Protein, His Tag	Mouse	HEK293 Cells	50ug, 100ug, 200ug	Inquiry

The featured target CD28 antibody products launched by KMD Bioscience:

CAT#	Products Name	Specise	Host	Appliance	Size	Inquiry
PA10946	Rabbit Anti-Human CD28 pAb	Human	Rabbit	WB	50ul, 100ul	Inquiry
YR1618	Anti-Human CD28 Recombinant Antibody(Anti-CD28)				1mg, 5mg	Inquiry

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